Anti-p40 Protein (ZR8) | 579-PP040-1.0

Product type:

Antibody

Product name:

P40 protein, delta-np63 (zr8)

Catalog:

Pp040-0.5

Quantity:

0.5 ml

Clonality:

Monoclonal

Host:

Rabbit

Conjugate:

Nonconjugated

Clone name:

Zr8

Application:

Immunohistochemistry - paraffin section

Cross=reactivity:

Human

Immunogen:

Synthetic polypeptides from n-terminal domaine of p63

Background:

P63 consists of two major isoforms-tap63 and dnp63. These isoforms differ in the structure of the n-terminal domains. The tap63 isoform (identified by anti-p63 antibody) contains a transactivation-competent ‘ta’ domain with homology to p53, which regulates the expression of the growth-inhibitory genes. In contrast, dnp63 isoform (identified by anti-p40 antibody) contains an alternative transcriptionally-inactive ‘dn’ domain, which antagonizes the activity of tap63 and p53.