Cholera Toxin Antibody (B subunit) | 544-MBS835672
Species Reactivity Bacteria
Published species Bacteria
Host/Isotype Rabbit / IgG
Immunogen Purified Choleragenoid.
Concentration 1 mg/mL
Storage buffer PBS, pH 7.2, with 1% BSA
Contains 0.002% thimerosal
Storage conditions 4°C or -20°C if preferred
Product Specific Information
PA1-85293 is specific for the beta subunit of Cholera toxin in bacterial samples.
This product has an Enzyme: Protein (Molar Ratio) of 2-3.
Rabbit anti cholera toxin beta antibody recognizes the beta subunit of cholera toxin.
Cholera toxin (sometimes abbreviated to CTX, Ctx, or CT) is a protein complex secreted by the bacterium Vibrio cholerae. CTX is the causative agent of cholera infection. The alpha subunit contains two chains, A1 and A2, linked by a disulfide bridge. The alpha subunit activates the adenylate cyclase enzyme in cells of the intestinal mucosa leading to increased levels of intracellular cAMP.
The beta subunit of cholera toxin binds to a GM1-ganglioside receptor which is widely accepted to initiate toxin action by triggering uptake and delivery of the toxin alpha subunit into cells. The holotoxin consists of a pentameric ring of beta subunits whose central pore is occupied by the alpha subunit.